SE447256B - 2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition derav - Google Patents
2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition deravInfo
- Publication number
- SE447256B SE447256B SE8201631A SE8201631A SE447256B SE 447256 B SE447256 B SE 447256B SE 8201631 A SE8201631 A SE 8201631A SE 8201631 A SE8201631 A SE 8201631A SE 447256 B SE447256 B SE 447256B
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- chlorophenyl
- triazol
- ethyl
- propyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- -1 3- (4- (3-chlorophenyl) -1-piperazinyl) propyl Chemical group 0.000 claims description 79
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- 150000001875 compounds Chemical class 0.000 claims description 46
- 229910052736 halogen Inorganic materials 0.000 claims description 22
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/244,464 US4338317A (en) | 1981-03-16 | 1981-03-16 | Phenoxyethyl-1,2,4,-triazol-3-one antidepressants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8201631L SE8201631L (sv) | 1982-09-17 |
| SE447256B true SE447256B (sv) | 1986-11-03 |
Family
ID=22922879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8201631A SE447256B (sv) | 1981-03-16 | 1982-03-15 | 2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition derav |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4338317A (en]) |
| JP (1) | JPS57159774A (en]) |
| KR (1) | KR880001374B1 (en]) |
| AT (1) | AT384022B (en]) |
| BE (1) | BE892503A (en]) |
| CA (1) | CA1198436A (en]) |
| CH (1) | CH649539A5 (en]) |
| CY (1) | CY1373A (en]) |
| DE (1) | DE3209557A1 (en]) |
| DK (1) | DK158728C (en]) |
| ES (1) | ES8305756A1 (en]) |
| FI (1) | FI73670C (en]) |
| FR (1) | FR2501690B1 (en]) |
| GB (1) | GB2096137B (en]) |
| GR (1) | GR76076B (en]) |
| HK (1) | HK4788A (en]) |
| IE (1) | IE52788B1 (en]) |
| IT (1) | IT1148137B (en]) |
| KE (1) | KE3711A (en]) |
| LU (1) | LU84011A1 (en]) |
| MX (1) | MX9203176A (en]) |
| NL (2) | NL190757C (en]) |
| SE (1) | SE447256B (en]) |
| SG (1) | SG30287G (en]) |
| YU (1) | YU43256B (en]) |
| ZA (1) | ZA821359B (en]) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399693A (en) * | 1984-04-17 | 1995-03-21 | British Technology Group Limited | Substituted piperazine-2-carboxylic acids and derivatives thereof |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487773A (en) * | 1981-03-16 | 1984-12-11 | Mead Johnson & Company | 1,2,4-Triazol-3-one antidepressants |
| US4386091A (en) * | 1982-02-24 | 1983-05-31 | Mead Johnson & Company | 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants |
| US4575555A (en) * | 1983-06-29 | 1986-03-11 | Mead Johnson & Company | 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative |
| AT388555B (de) * | 1983-06-29 | 1989-07-25 | Bristol Myers Co | Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten |
| US4613600A (en) * | 1983-09-30 | 1986-09-23 | Mead Johnson & Company | Antidepressant 1,2,4-triazolone compounds |
| YU44721B (en) * | 1983-11-30 | 1990-12-31 | Bristol Myers Co | Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone |
| US4784998A (en) * | 1987-04-06 | 1988-11-15 | Bristol-Myers Company | 1,3,4-oxadiazole pyschotropic compounds |
| US5116852A (en) * | 1990-12-03 | 1992-05-26 | Bristol-Myers Squibb Co. | Treatment of sleep disorders |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| US5256664A (en) * | 1992-04-28 | 1993-10-26 | Bristol-Myers Squibb Company | Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones |
| IT1256387B (it) * | 1992-11-13 | 1995-12-04 | Acraf | Procedimento per preparare triazoloni |
| DE4425144A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Triazolverbindungen und deren Verwendung |
| CA2160423A1 (en) * | 1994-11-02 | 1996-05-03 | Hemant N. Joshi | Salts of nefazodone having improved dissolution rates |
| AU7025396A (en) | 1995-10-17 | 1997-05-01 | Bristol-Myers Squibb Company | Nefazodone: treatment of panic attack |
| CA2182241C (en) * | 1996-07-29 | 2002-09-17 | Bo Lei | Methods for the manufacture of nefazodone |
| WO1998004261A1 (en) * | 1996-07-31 | 1998-02-05 | Bristol-Myers Squibb Company | Nefazodone: use in migraine prophylaxis |
| US5852020A (en) * | 1996-11-22 | 1998-12-22 | Bristol-Myers Squibb Company | Nefazodone: use in treating post traumatic stress disorder |
| US5735873A (en) * | 1996-12-19 | 1998-04-07 | Maclean; David S. | Surgical tool handle |
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| IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
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1981
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- 1982-03-12 DK DK112582A patent/DK158728C/da not_active IP Right Cessation
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399693A (en) * | 1984-04-17 | 1995-03-21 | British Technology Group Limited | Substituted piperazine-2-carboxylic acids and derivatives thereof |
| US5595983A (en) * | 1984-04-17 | 1997-01-21 | British Technology Group Limited | Substituted piperazine 2-carboxylic acids useful in the treatment of central nervous system disorders |
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